How much vinegar should you use to clean a 12 cup coffee maker? Posted on September 22, 2022 By admin How Much Vinegar To Use To Clean a Coffee Maker. A 12-cup coffee pot makes 12, 5-ounce cups of coffee, or 60 ounces total. You’ll need 30 ounces of vinegar and 30 ounces of water to deep clean it.